Russell Ryan, MD, and his team’s discovery appears to address longstanding mysteries about mutations found in B-cell acute lymphoblastic leukemia

University of Michigan Rogel Cancer Center researchers find ZMYND8 gene plays a critical role in conferring radiation resistance on brain tumors with IDH1 mutation.

For some patients, immunotherapy furthers tumor progression instead of halting it. What distinguishes those who benefit from those who don’t?

Mouse models show that activating a non-mutated form of the gene could lead to developing therapies for this deadly form of cancer. 

A new study in cells and mice from the University of Michigan Rogel Cancer Center has found that a low-protein diet and a specific reduction in amino acids can improve treatment for colon cancer.

Precision oncology approach shows potential for high grade gliomas harboring a genetic mutation.

A rare bile duct cancer was difficult to treat once it spread to the lining of Lori Robertson’s abdomen. A clinical trial, led by University of Michigan Health, gave her some other options.

In cell-line and mouse models of ovarian cancer, researchers developed an interdisciplinary approach to identify metabolic vulnerabilities in certain genes that could be targeted to kill cancer cells.

A clearer picture of how a cell is organized could help biologists learn how to reprogram a cell to halt cancer or other diseases.

Biopsies from the same patients before and after treatment reveal how a specific drug reprograms prostate tumors.

A clinical trial in head and neck cancer explored ways to improve clinical outcomes for patients. Although the trial failed, researchers found insight into new ways to address treatment resistance.

GOT2 causes metabolic changes that pancreas tumors overcome.

By using the lymphatic system as a storage reservoir, researchers found they could optimize drug concentrations to simultaneously target two molecular signaling pathways responsible for cancer growth.

Molecular changes in nonalcoholic fatty liver disease could serve as potential therapeutic targets to halt the cells’ progression to liver cancer.

Breakthroughs in the field of genomics are revolutionizing prevention, diagnosis and care.